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During one of our recent projects we built an combined atomic force microscope and total internal reflection microscope. In collaboration with Pedro de Pablo
(Universidad Autónoma de Madrid) and Urs Greber (University of Zurich) we used this instrument to study the the genome release of viruses (Ortega-Esteban et al. 2015).

Figure 1: AFM unpacking of adenovirus
A cartoon of the experiment shows the unpacking experiment. By using Yoyo-1 as fluorescent label we can track the release of the viral DNA. The full animation can be found here.