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During one of our recent projects we combined atomic force microscopy with total internal reflection microscope to
study the the genome release of viruses (Ortega-Esteban et al. 2015). This work was performed in collaboration with Pedro de Pablo (Universidad Autónoma de Madrid) and Urs Greber (University of Zurich).

Figure 1: AFM unpacking of adenovirus
A cartoon of the experiment shows the unpacking experiment. By using Yoyo-1 as fluorescent label we can track the release of the viral DNA. The full animation can be found here.